ANTICANCER EFFECTS OF TOW TRADITIONAL DRINKS HIBISCUS (Hibiscus sabdariffa LINN) AND LIQUORICE (Glycyrrhiza glabra)

Elkattan, Ahmed N.; El-Saadany, S. S.; ElSayed, A. L.; Gomaa, A. M.; Abdalmuneim, J.

doi:10.21608/zjar.2019.40329

ANTICANCER EFFECTS OF TOW TRADITIONAL DRINKS HIBISCUS (Hibiscus sabdariffa LINN) AND LIQUORICE (Glycyrrhiza glabra)

Document Type : Original Article

Authors

¹ Biochem. Dept., Fac. Agric., Zagazig Univ., Egypt

² Fac. Vet., Zagazig Univ., Egypt

10.21608/zjar.2019.40329

Abstract

Breast cancer (MCF-7), as well as liver cancer (HepG2), were the leader among new
cancer cases. The objective of this study is to assess the viability percentage of tow traditional drinks
(hibiscus and liquorice extracts) toward human breast and liver cancer cell lines at different
concentrates from 250 to 5000 μg/ml in hibiscus extract and from 50 to 3000 μg/ml in liquorice
extract. The viability percentage of hibiscus on breast and liver cancer cell lines were 86.9% and
84.7% at 5000 μg/ml, respectively. The IC50 of the hibiscus extract were 18478.6 μg/ml and 16159
μg/ml breast and liver cancer. In addition, the viability percentage of liquorice extract on breast and
liver cancer cell lines were determined. Results revealed that liquorice extract has possessed high anticarcinogenic
properties it was zero (%) at 3000 μg/ml for breast cancer and 5% for liver cancer at
same concentration, the IC50 was 491.7 μg/ml in breast cancer and was 125 μg/ml in liver cancer cell
line. DNA damage was determined to detect oxidative DNA damage in HepG2 cell line. This enhances the
role of these traditional drinks especially liquorice as anti-cancer agents.

Keywords